Presence of a novel exon 2E encoding a putative transmembrane protein in human IL-33 gene |
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| Authors: | Shin-ichi Tominaga Morisada Hayakawa Hidetoshi Tsuda Satoshi Ohta Ken Yanagisawa |
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| Institution: | 1. Department of Human Anatomy, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu Province 210029, China;2. Norton Neuroscience Institute, Norton Healthcare, 210 E. Gray Street, Suite 1102, Louisville, KY 40202, USA;3. Department of Discovery Biology, Biogen Idec Inc., 14 Cambridge Center, Cambridge, MA 02142, USA;1. Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany;2. Department of Pediatrics, FAU Erlangen–Nürnberg, Erlangen, Germany;3. Department of Pathology, Salzburger Landeskliniken, Salzburg, Austria;4. Department of Cardiac Surgery, FAU Erlangen–Nürnberg, Erlangen, Germany;5. Department of Nephrology and Hypertension, FAU Erlangen–Nürnberg, Erlangen, Germany |
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| Abstract: | Interleukin-33 (IL-33) is a dual-function molecule that regulates gene expression in nuclei and, as a cytokine, conveys proinflammatory signals from outside of cells via its specific receptor ST2L. There are still a lot of questions about localization and processing of IL-33 gene products. In the course of re-evaluating human IL-33 gene, we found distinct promoter usage depending on the cell type, similar to the case in the ST2 gene. Furthermore, we found a novel exon 2E in the conventional intron 2 whose open reading frame corresponded to a transmembrane protein of 131 amino acids. Dependence of exon 2E expression on differentiation of HUVEC cells is of great interest in relation to human IL-33 function. |
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