Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degeneration |
| |
| Authors: | Youn Ho Shin Seo Jin Lee Junyang Jung |
| |
| Institution: | 2. Université Paris-Est Créteil, Créteil, France;3. CNRS UMR3244, Centre de Recherche, Institut Curie, Paris, France;4. Département de Pathologie, Plateforme de Ressources Biologiques, Hôpital H. Mondor-A. Chenevier, AP-HP, Créteil, France;5. Faculté de Médecine/Signalisation et Cancer de la Prostate/EA4438, Université Strasbourg, Strasbourg, France;1. Department of Urology, Zhejiang Cancer Hospital, Hangzhou, China;2. Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou, China;3. Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, China;4. Department of Urology, Sen-en General Hospital, Tagajo, Miyagi, Japan;5. Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan;1. Department of Neurology and Clinical Neurophysiology, St. Elisabeth Ziekenhuis, Tilburg, The Netherlands;2. Department of Neurology, Gemini Ziekenhuis, Den Helder, The Netherlands;1. Division of Molecular Cell Biology, Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo 105-8461, Japan;2. Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Republic of Korea;3. Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6T 2B5;4. Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan;1. Centre Hospitalier du Valais Romand (CHVR), Sierre, Switzerland;2. Center for Hand Surgery and Therapy, Geneva, Switzerland;1. Respiratory Viruses Research Laboratory, Discovery Biology Department, Institut Pasteur Korea, Republic of Korea;2. Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Republic of Korea |
| |
| Abstract: | After nerve injury, Schwann cells proliferate and revert to a phenotype that supports nerve regeneration. This phenotype-changing process can be viewed as Schwann cell dedifferentiation. Here, we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation in sciatic explants, we found that extracellular ATP inhibits Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Furthermore, the blockage of lysosomal exocytosis in ATP-treated sciatic explants is sufficient to induce Schwann cell dedifferentiation. Together, these findings suggest that ATP-induced lysosomal exocytosis may be involved in Schwann cell dedifferentiation. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
