<Emphasis Type="Italic">KIR</Emphasis> gene content diversity in four Iranian populations |
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Authors: | Elham Ashouri Shirin Farjadian Elaine F Reed Abbas Ghaderi Raja Rajalingam |
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Institution: | (1) UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California at Los Angeles, 1000 Veteran Avenue, Room # 1-536, Box 951652, Los Angeles, CA 90095-1652, USA;(2) Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, P.O. Box 71345-1798, Shiraz, Iran;(3) Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran |
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Abstract: | Killer cell immunoglobulin-like receptors (KIR) regulate natural killer cell response against infection and malignancy. KIR genes are variable in the number and type, thereby discriminating individuals and populations. Herein, we analyzed the KIR gene content diversity in four native populations of Iran. The KIR genomic diversity was comparable between Bakhtiari and Persian and displayed a balance of A and B KIR haplotypes, a trend reported in Caucasian and African populations. The KIR gene content profiles of Arab and Azeri were comparable and displayed a preponderance of B haplotypes, a scenario reported
in the natives of America, India, and Australia. A majority of the B haplotype carriers of Azeri and Arab had a centromeric
gene-cluster (KIR2DS2-2DL2-2DS3-2DL5). Remarkably, this cluster was totally absent from the American natives but occurred at highest frequencies in the natives
of India and Australia in combination with another gene cluster at the telomeric region (KIR3DS1-2DL5-2DS5-2DS1). Therefore, despite having similar frequencies of B haplotypes, the occurrence of B haplotype-specific KIR genes, such as 2DL2, 2DL5, 3DS1, 2DS1, 2DS2, 2DS3, and 2DS5 in Azeri and Arab were substantially different from the natives of America, India, and Australia. In conclusion, each Iranian
population exhibits distinct KIR gene content diversity, and the Indo-European KIR genetic signatures of the Iranians concur with geographic proximity, linguistic affinity, and human migrations.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | NK cells KIR genes Immunity-related genes Polymorphism Iranian populations Persian |
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