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Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases |
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| Authors: | Zificsak Craig A Gingrich Diane E Breslin Henry J Dunn Derek D Milkiewicz Karen L Theroff Jay P Thieu Tho V Underiner Ted L Weinberg Linda R Aimone Lisa D Albom Mark S Mason Jennifer L Saville Lisa Husten Jean Angeles Thelma S Finn James P Jan Mahfuza O'Kane Teresa M Dobrzanski Pawel Dorsey Bruce D |
| Institution: | Worldwide Discovery Research, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA. czificsa@cephalon.com |
| Abstract: | The elaboration of a novel scaffold for the inhibition of JAK2 and FAK kinases was targeted in order to provide a dual inhibitor that could target divergent pathways for tumor cell progression. |
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