Department of Cell Biology and Anatomy, Hematology/Oncology Division, Cornell University Medical College, 1300 York Avenue, New York, NY, 10021, U.S.A. Tel.: 212-746-6166; Fax: 212-746-8961
Abstract:
Although ligand-induced dimerization or oligomerization of receptors is a well established mechanism of growth factor signaling, increasing evidence indicates that biological responses are often mediated by receptor trans-signaling mechanisms involving two or more receptor systems. These include G protein-coupled receptors, cytokine, growth factor and trophic factor receptors. Greater responsiveness and inhibitory signaling responses are provided when different signaling pathways merge through receptor trans-signaling.