Effects of A and B prostaglandins on cAMP, cortisol, and aldosterone production by the human adrenal. |
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Authors: | K V Honn W Chavin |
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Institution: | Departments of Radiology and Biology Wayne State University, Detroit, Michigan 48202 USA |
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Abstract: | PGA1 and PGA2 (10, 100 μg/ml) significantly increased human adrenal cAMP levels and cortisol output but low doses (1 μg/ml) depressed both parameters. Only 1 μg/ml PGA1 significantly increased aldosterone output while higher doses depressed same. The low PGA2 dose (1 μg/ml) depressed aldosterone output. The glucocorticoid and mineralocorticoid outputs appear to be inversely modulated by prostaglandins. PGB1 and PGB2 behaved similarly to E type prostaglandins. However, like PGA1, 1 μg/ml of PGB1 or PGB2 significantly increased aldosterone output. Higher doses were ineffective. The present findings reveal an increased complexity of prostaglandin modulation of cyclic nucleotides and steroid output. |
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