Snapshots of mammary gland interstitial cells: methylene-blue vital staining and c-kit immunopositivity |
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Authors: | Popescu L M Andrei F Hinescu M E |
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Institution: | Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania. LMP@univermed-cdgm.ro |
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Abstract: | We show here that methylene-blue supravital staining of specimens from normal human mammary gland reveals (selectively) interstitial (stromal) cells, with 2-3 long (20-80 microm), thin, moniliform processes. Such cells appear c-kit/CD117 positive, either by immunohistochemistry (IHC) or immunofluorescence (IF). Since these features (affinity for methylene blue, c-kit positivity, and characteristic processes) define archetypal interstitial cells of Cajal (ICC) in light microscopy, our results suggest the existence of Cajal-like cells in the interstitium of human normal mammary gland. |
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Keywords: | human mammary-gland methylene-blue vital staining CD117 interstitial cells of Cajal Cajal-like cells cell processes stromal cells |
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