400 MHz NMR study on the C-terminal fragment 21–28 of vasoactive intestinal peptide |
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Authors: | Alain Fournier John K Saunders Serge St-Pierre |
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Institution: | Department of Physiology and Pharmacology, Faculty of Medicine, University of Sherbrooke Sherbrooke, Quebec, Canada J1H 5N4 |
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Abstract: | A conformational study of the C-terminal fragment 21–28 of vasoactive intestinal peptide (VIP) was carried out by high resolution NMR spectroscopy. All spectral data were recorded with a Brüker 400 MHz spectrometer. The correct assignment of peaks was determined by specific homonuclear decoupling and by titration. The chemical shifts of amide protons were measured as a function of temperature in order to detect the presence of intramolecular hydrogen bonds. A tridimensional structure is proposed for the peptide. |
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Keywords: | Vasoactive intestinal peptide High resolution NMR spectroscopy Conformational study |
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