Two chemically and immunologically distinct forms of luteinizing hormone-releasing hormone are differentially expressed in frog neural tissues |
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| Authors: | Lee E. Eiden Ernest Loumaye Nancy Sherwood Robert L. Eskay |
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| Affiliation: | 1. Unit on Neuroendocrinology, Laboratory of Clinical Science National Institute of Mental Health, Bethesda, MD 20205 USA;2. Endocrinology and Reproductive Research Branch National Institute of Child Health and Human Development, Bethesda, MD 20205 USA |
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| Abstract: | Immunoreactive luteinizing hormone-releasing hormone (IR-LRF) has been measured in several neural tissues of the frog Rana catesbeiana and characterized by bioassay, chromatography and immunological analysis. Frog brain contains the mammalian form of LRF (mLRF), whereas, sympathetic ganglia and adrenal glands contain a form of LRF (pLRF) chromatographically and immunologically similar to the IR-LRF found in the central nervous systems of several piscine species. Frog retina contains both mLRF and pLRF, in a ratio of about 1:2. The two forms of LRF are apparently equipotent in their ability to release LH from rat gonadotrophs in vitro. Immunological analysis of the pLRF found in the frog nervous system suggests that it is a decapeptide, like mLRF, with one or more amino acid substitutions in the mLRF molecule. |
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| Keywords: | Amphibian and piscine LRF Sympathetic nervous system Retina Adrenal gland |
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