The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin |
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| Authors: | M Cochran J Coates S Neoh |
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| Institution: | Department of Medicine and Immunology, Flinders Medical Centre, Bedford Park, 5042 Australia;Department of Physical Chemistry, University of Adelaide, Adelaide, 5000 Australia |
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| Abstract: | Human transferrin is shown to bind 2 mol of aluminium per mol of protein using spectrophotometric titration. Competitive equilibrium between aluminium and ferric ions for transferrin binding sites is observed, and a value of 2.5 (+/- 0.4) X 10(15) M-1 is found for the apparent binding constant under physiological conditions. |
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| Keywords: | Human transferrin Aluminium binding constant Molar relationship Aluminium-iron competition optical density at 240 nm |
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