Phosphorylase-mediated mobilization of the amino group of adenine in Bacillus cereus |
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Institution: | 1. Aksaray University, Technical Vocational School, Department of Chemistry Technology, 68100 Aksaray, Turkey;2. Aksaray University, Faculty of Science and Letters, Department of Chemistry, 68100 Aksaray, Turkey |
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Abstract: | Mobilization of the ribose moiety of purine nucleosides as well as of the amino group of adenine may be realized in Bacillus cereus by the concerted action of three enzymes: adenosine phosphorylase, adenosine deaminase, and purine nucleoside phosphorylase. In this pathway, ribose-1-phosphate and inorganic phosphate act catalytically, being continuously regenerated by purine nucleoside phosphorylase and adenosine phosphorylase, respectively. As a result of such a metabolic pathway, adenine is quantitatively converted into hypoxanthine, thus overcoming the lack of adenase in B. cereus. |
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