Detection of blaSHV, blaTEM and blaCTX-M antibiotic resistance genes in randomly selected bacterial pathogens from the Steve Biko Academic Hospital |
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| Authors: | Marthie M. Ehlers,Chrisna Veldsman,Eddy P. Makgotlho,Michael G. Dove,Anwar A. Hoosen,& Marleen M. Kock |
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| Affiliation: | Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria/NHLS, Pretoria, South Africa |
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| Abstract: | Extended-spectrum β-lactamases (ESBLs) are considered to be one of the most important antibiotic resistance mechanisms. This study reported the ESBL-producing genes in 53 randomly selected clinical bacterial isolates from the Steve Biko Academic Hospital. The presence of the bla SHV, bla TEM and bla CTX-M genes was determined, and the overall prevalence of these genes detected in this study was 87% (46/53) in comparison with the literature; these results were higher when compared with 33% for Escherichia coli in Europe and 0.8% in Denmark for similar pathogens. These research findings indicated that it is crucial to routinely monitor the prevalence of these resistance genes. |
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| Keywords: | extended-spectrum β-lactamases cefotaximase temoniera sulfhydryl variable |
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