| 复合诱变和抗性筛选利迪链菌素高产菌株 |
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| 引用本文： | 郭卫寰,李小兵,元英进. 复合诱变和抗性筛选利迪链菌素高产菌株[J]. 微生物学报, 2007, 34(5): 0831-0835 |
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| 作者姓名： | 郭卫寰 李小兵 元英进 |
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| 作者单位： | 天津大学化工学院制药工程系 天津 300072;天津大学化工学院制药工程系 天津 300072;天津大学化工学院制药工程系 天津 300072 |
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| 基金项目： | 国家自然科学基金资助项目(No.20425620) |
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| 摘 要： | 为解决利迪链霉菌生产能力低的问题，以Streptomyces lydicus AS 4.2501-P28为出发菌株，应用紫外和吖啶橙诱变，结合抗生素的抗性筛选，得到稳定高产的S. lydicus AS 4.2501-L8，发酵水平达到177.0 μg/mL，较出发菌株提高了96.2%。
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| 关 键 词： | 利迪链霉菌， 利迪链菌素， 复合诱变， 抗性筛选 |
Breeding of High Streptolydigin-Producing Strain by Complex Mutagenesis and Resistance Selection |
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| GUO Wei-Huan,LI Xiao-Bing and YUAN Ying-Jin. Breeding of High Streptolydigin-Producing Strain by Complex Mutagenesis and Resistance Selection[J]. Acta microbiologica Sinica, 2007, 34(5): 0831-0835 |
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| Authors: | GUO Wei-Huan LI Xiao-Bing YUAN Ying-Jin |
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| Affiliation: | Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 |
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| Abstract: | |
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| Keywords: | Streptomyces lydicus Streptolydigin Complex mutagenesis Resistance selection |
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