Polymorphism of human erythrocyte carbonic anhydrase in the population of Moscow and in the native populations of Siberia detected by polyacrylamide gel electrophoresis

Carbonic anhydrase of human erythrocytes was separated by polyacrylamide electrophoresis into four fractions determined, obviously, by two loci, CAI and CAII. Investigation of Moscow population sample of 458 men (516 healthy and 42 with schizophrenia) showed monomorphism of carbonic anhydrase for these two loci. Carbonic anhydrase I and carbonic anhydrase II were differentiated with fluorogenic substrates. The polymorphic variant of CAII was discovered while studying the sample of Siberian mongoloids (Evenks and Jakuts) with frequency 0,047 and 0,045, respectively.