RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia |
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| Authors: | Lagu Bharat Pio Barbara Lebedev Rimma Yang Maria Pelton Patricia D |
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| Institution: | Johnson and Johnson Pharmaceutical Research and Development, Cranbury, NJ 08869, USA. blagu@prdus.jnj.com |
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| Abstract: | A number of RXR agonists were synthesized and screened in functional assays. The synthesis and the structure-activity relationship (SAR) within the series of compounds will be presented. Some in vivo data in rodent models for dyslipidemia and diabetes will also be presented. |
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