Semisyngeneic hybrid resistance to murine teratocarcinoma cells |
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| Authors: | Gail Abendroth Bishop William F. Dove |
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| Affiliation: | (1) McArdle Laboratory for Cancer Research, The University of Wisconsin, 53706 Madison, Wisconsin;(2) Present address: Program in Cellular and Molecular Biology, University of Michigan, 48109 Ann Arbor, Michigan |
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| Abstract: | Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngeneic 129/J parent strain. All hybrid strains tested showed significantly higher resistance to the nullipotent embryonal carcinoma line F9 than the syngeneic strain.Hybrid resistance to embryonal carcinoma lines does not require a hybridH-2 complex.Several kinds of evidence indicate that this hybrid resistance has an immunological basis. |
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