The hylEfm gene in pHylEfm of Enterococcus faecium is not required in pathogenesis of murine peritonitis |
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| Authors: | Panesso Diana Montealegre Maria C Rincón Sandra Mojica Maria F Rice Louis B Singh Kavindra V Murray Barbara E Arias Cesar A |
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| Institution: | Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Reemerging Pathogens, Houston, TX, USA. |
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| Abstract: | Background Plasmids containing hyl
Efm
(pHylEfm) were previously shown to increase gastrointestinal colonization and lethality of Enterococcus faecium in experimental peritonitis. The hyl
Efm
gene, predicting a glycosyl hydrolase, has been considered as a virulence determinant of hospital-associated E. faecium, although its direct contribution to virulence has not been investigated. Here, we constructed mutants of the hyl
Efm
-region and we evaluated their effect on virulence using a murine peritonitis model. |
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