Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility |
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| Authors: | David A Quigley Minh D To Il Jin Kim Kevin K Lin Donna G Albertson Jonas Sjolund Jesús Pérez-Losada Allan Balmain |
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| Affiliation: | 1.Helen Diller Family Comprehensive Cancer Center,University of California San Francisco,San Francisco,USA;2.Thoracic Oncology Program, Department of Surgery,University of California San Francisco,San Francisco,USA;3.Department of Laboratory Medicine,University of California San Francisco,San Francisco,USA;4.Instituto de Biología Molecular y Celular del Cáncer,CSIC/Universidad de Salamanca,Salamanca,Spain |
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| Abstract: | Background Germline polymorphisms can influence gene expression networks in normal mammalian tissues and can affect disease susceptibility. We and others have shown that analysis of this genetic architecture can identify single genes and whole pathways that influence complex traits, including inflammation and cancer susceptibility. Whether germline variants affect gene expression in tumors that have undergone somatic alterations, and the extent to which these variants influence tumor progression, is unknown. |
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