Network based transcription factor analysis of regenerating axolotl limbs期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Network based transcription factor analysis of regenerating axolotl limbs

Authors:	Deepali Jhamb Nandini Rao Derek J Milner Fengyu Song Jo Ann Cameron David L Stocum Mathew J Palakal

Affiliation:	(1) School of Informatics, Indiana University-Purdue University Indianapolis, 46202 Indianapolis, IN, USA;(2) Department of Biology, Indiana University-Purdue University Indianapolis, 46202 Indianapolis, IN, USA;(3) Department of Cell and Developmental Biology, and Regeneration Biology and Tissue Engineering Theme, Institute for Genomic Biology, University of Illinois-Urbana Champaign, 61801 Urbana, IL, USA;(4) Department of Oral Biology, School of Dentistry, Indiana University-Purdue University Indianapolis, 46202 Indianapolis, IN, USA;(5) Center for Regenerative Biology and Medicine, Indiana University-Purdue University Indianapolis, 46202 Indianapolis, IN, USA;(6) College of Medicine, American University of Antigua, P. O. Box W-1451, University Park, Jabberwock, Coolidge, Antigua, West Indies

Abstract:	Background Studies on amphibian limb regeneration began in the early 1700's but we still do not completely understand the cellular and molecular events of this unique process. Understanding a complex biological process such as limb regeneration is more complicated than the knowledge of the individual genes or proteins involved. Here we followed a systems biology approach in an effort to construct the networks and pathways of protein interactions involved in formation of the accumulation blastema in regenerating axolotl limbs.

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