Position and sequence conservation in Amniota of polymorphic enhancer HS1.2 within the palindrome of IgH 3'Regulatory Region |
| |
| Authors: | Pietro D’Addabbo Moira Scascitelli Vincenzo Giambra Mariano Rocchi Domenico Frezza |
| |
| Affiliation: | (1) Department of Genetics and Microbiology, University of Bari, Bari, Italy;(2) Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada;(3) BC Cancer Agency, Terry Fox Laboratory, Vancouver, British Columbia, Canada;(4) Department of Biology, Viale della ricerca scientifica, University of Roma Tor Vergata, Roma, 00133, Italy |
| |
| Abstract: | Background The Immunoglobulin heavy chain (IgH) 3' Regulatory Region (3'RR), located at the 3' of the constant alpha gene, plays a crucial role in immunoglobulin production. In humans, there are 2 copies of the 3'RR, each composed of 4 main elements: 3 enhancers and a 20 bp tandem repeat. The single mouse 3'RR differs from the two human ones for the presence of 4 more regulative elements with the double copy of one enhancer at the border of a palindromic region. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
