Bioinformatics analysis of disordered proteins in prokaryotes |
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| Authors: | Gordana M Pavlović-Lažetić Nenad S Mitić Jovana J Kovačević Zoran Obradović Saša N Malkov Miloš V Beljanski |
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| Institution: | (1) Faculty of Mathematics, University of Belgrade, Studentski trg 16, P.O.B. 550, 11001 Belgrade, Serbia;(2) Center for Information Science and Technology, Temple University, 303 Wachman Hall (038-24), 1805 N. Broad St, 19122 Philadelphia, PA, USA;(3) Institute of General and Physical Chemistry, Studentski trg 16, P.O.B. 551, 11001 Belgrade, Serbia |
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| Abstract: | Background A significant number of proteins have been shown to be intrinsically disordered, meaning that they lack a fixed 3 D structure
or contain regions that do not posses a well defined 3 D structure. It has also been proven that a protein's disorder content
is related to its function. We have performed an exhaustive analysis and comparison of the disorder content of proteins from
prokaryotic organisms (i.e., superkingdoms Archaea and Bacteria) with respect to functional categories they belong to, i.e.,
Clusters of Orthologous Groups of proteins (COGs) and groups of COGs-Cellular processes (Cp), Information storage and processing
(Isp), Metabolism (Me) and Poorly characterized (Pc). |
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