An actinomycete producing L-3,4-dihydroxyphenylalanine from L-tyrosine |
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Authors: | C. P. Sukumaram D. V. Singh P. D. Khedkar P. R. Mahadevan |
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Affiliation: | (1) Central Research Laboratory, Indian Drugs and Pharmaceuticals Limited, Rishikesh, 249 202 Virbhadra;(2) Foundation for Medical Research, 84-A, R. G. Thadani Marg, 400018 Bombay |
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Abstract: | An actinomycete was isolated during a soil screening programme to obtain L-3,4-dihydroxyphenylalanine producers. A mutant of this organism was isolated by chemical mutagenesis and it accumulated 1 g/litre L-dihydroxyphenylalanine when grown on L-tyrosine. Resting cells converted 30% of tyrosine in the reaction mixture. The use of resting cells for dihydroxyphenylalanine production is advantageous as it eliminates interfering substances which accumulate during fermentation. |
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Keywords: | Actinomycete L-dihydroxyphenylalanine production fermentation |
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