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NAD Glycohydrolases: A possible function in calcium homeostasis |
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| Authors: | Hyuntae Kim Elaine L. Jacobson Myron K. Jacobson |
| Affiliation: | (1) Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, 76017 Lexington, KY, USA;(2) Department of Clinical Sciences, College of Allied Health Professions, University of Kentucky, 76017 Lexington, KY, USA;(3) Lucille P. Markey Cancer Center, University of Kentucky, 76017 Lexington, KY, USA |
| Abstract: | NAD glycohydrolases are the longest known enzymes that catalyze ADP-ribose transfer. The function of these ubiquitous, membrane-bound enzymes has been a long standing puzzle. The NAD glycohydrolase are briefly reviewed in light of the discovery by our laboratory that NAD glycohydrolases are bifunctional enzymes that can catalyze both the synthesis and hydrolysis of cyclic ADP-ribose, a putative second messenger of calcium homeostasis.Abbreviations NADase nicotinamide adenine dinucleotide glycohydrolase - NAD nicotinamide adenine dinucleotide - ADP-ribose adenosine diphosphoribose - cADPR cyclic adenosine diphosphoribose |
| Keywords: | NAD glycohydrolases cyclic ADP-ribose ADP-ribose transfer calcium homeostasis nicotinamide adeniner dinucleotide |
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