Microarray-based genomic surveying of gene polymorphisms in <Emphasis Type="Italic">Chlamydia trachomatis</Emphasis>期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Microarray-based genomic surveying of gene polymorphisms in <Emphasis Type="Italic">Chlamydia trachomatis</Emphasis>

Authors:	Brian?W?Brunelle Tracy?L?Nicholson Email author" target="_blank">Richard?S?Stephens Email author

Institution:	(1) Program in Infectious Diseases, University of California, 94720-7360 Berkeley, CA, USA;(2) Francis I. Proctor Foundation, University of California, 94143-0412 San Francisco, CA, USA;

Abstract:	By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis.

Keywords:
本文献已被 PubMed SpringerLink 等数据库收录！