Serine Transhydroxymethylase Activity in Vertebrate Retina |
| |
| Authors: | P Dasgupta A Narayanaswami |
| |
| Institution: | Department of Fundamental Biochemistry, Indian Institute of Experimental Medicine, Calcutta, India |
| |
| Abstract: | Abstract: The presence of serine transhydroxymethylase (STHM; EC 2.1.2.1) in crude homogenates of rat, guinea pig and goat retina has been demonstrated. There was a variation in the levels of retinal STHM activity in the three species. Substantial STHM activity was found in all the three retinal preparations in the absence of pyridoxal-5-phosphate in the incubation medium. There was direct correlation ( r = 0.995; p < 0.001) between the STHM activity and the glycine content in rat telencephalon, midbrain, medulla-pons, spinal cord and retina. These findings suggest that STHM is probably an important enzyme for the synthesis of neural glycine in the vertebrate retina. |
| |
| Keywords: | Serine transhydroxymethylase Retinal glycine metabolism |
|
|
