3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter |
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| Authors: | Blough B E Holmquist C R Abraham P Kuhar M J Carroll F I |
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| Institution: | Chemistry and Life Sciences, Research Triangle Institute, Research Trirangle Park, NC 27709, USA. |
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| Abstract: | A series of 3alpha-(4-substituted)nortropane-2beta-carboxylic acid methyl esters was synthesized and evaluated for the ability to inhibit radioligand binding at the dopamine, serotonin, and norepinephrine transporters. 3alpha-(4-Methylphenyl)nortropane-2beta-carboxylic acid methyl ester (4c) was found to be selective and highly potent for the norepinephrine transporter (NET) relative to the dopamine and serotonin transporters. |
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