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X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus |
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| Authors: | E. J. B. M. Mensink A. Thompson L. A. Sandkuyl M. E. M. Kraakman J. D. L. Schot T. Espanol R. K. B. Schuurman |
| Affiliation: | (1) Division of Immunobiology, Department of Immunohaematology, University Medical Center, NL-2300 RC Leiden, The Netherlands;(2) Department of Clinical Genetics, University Hospital Dijkzigt, NL-3000 DR Rotterdam, The Netherlands;(3) Department of Immunology, Clinica Infantil R.S. !["ldquo"]("/content/g85q4x7122171075/xlarge8220.gif") Valle de Hebron!["rdquo"]("/content/g85q4x7122171075/xlarge8221.gif") , E-35 Barcelona, Spain |
| Abstract: | Summary The gene involved in X-linked immunodeficiency with hyperimmunoglobulinemia M (XHM) was localized by the use of nine restriction fragment length polymorphic (RFLP) markers covering the entire X chromosome. Multipoint linkage analysis of RFLP data obtained in a three generation XHM pedigree indicates the Xq24-q27 area around the DXS42 RFLP locus as the most likely localization of the XHM locus. |
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