Specific effect of 5,6-dihydroxytryptamine on the monoamine fluorophore of the frog's gustatory cells |
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Authors: | O. Nada K. Hirata |
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Affiliation: | (1) Department of Medical Technology, Kyushu University School of Health Sciences, Fukuoka, Japan;(2) Department of Anatomy, Faculty of Medicine, Kyushu University, Fukuoka, Japan |
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Abstract: | Summary A specific formaldehyde-induced yellow fluorescence, suggesting the presence of serotonin-like monoamine has been demonstrated in the gustatory cells of the frog.The fungiform papillae of frogs were examined fluorescence-histochemically after intraperitoneal injection of 5,6-dihydroxytryptamine. The results indicated that the fluorophore of gustatory cells was affected selectively by the drug injection: the yellow fluorescence was transiently enhanced 3 hours after the drug injection, thereafter being reduced rapidly. The effect of 5,6-dihydroxytryptamine was long-lasting with the reduction of the yellow fluorophore persisting at least for the experimental duration of 14 days. A single injection of 6-hydroxydopamine induced a complete depletion of noradrenaline fluorescence from adrenergic nerve terminals, while the fluorescence of gustatory cells was not affected by a high dose of the drug.The present results with pharmacologic treatments further support the view that the gustatory cell of the frog contains a serotonin-like monoamine. |
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