Videoradiographic analysis of the range of motion in unilateral experimental knee joint arthritis in rats |
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| Authors: | Michael K Boettger Johannes Leuchtweis Hans-Georg Schaible Manuela Schmidt |
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| Institution: | (1) Institute of Physiology I/Neurophysiology, University Hospital, Teichgraben 8, D-07743 Jena, Germany;(2) Bayer Schering Pharma AG, Forschungszentrum Elberfeld, Aprather Weg 18 a, D-42113 Wuppertal, Germany;(3) Institute of Systematic Zoology and Evolutionary Biology, Friedrich-Schiller-University, Erbertstrasse 1, D-07743 Jena, Germany |
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| Abstract: | Introduction The translational and predictive value of animal models highly depends on the validity of respective readout parameters. In
arthritis research, there has been a shift from sole threshold testing for pain-related behavior, as well as from swelling
and histology assessment for inflammation, toward an analysis of joint function as indicated, for instance, by an increasing
number of studies on gait abnormalities. Clinically, the range of motion (ROM) of the affected joint plays a major role in
diagnosis and the assessment of treatment benefits. This parameter, however, is only insufficiently detected by currently
used analytic systems in animals. |
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| Keywords: | range of motion rat arthritis mechanical thresholds videoradiography readout parameter preclinical testing |
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