肝癌大鼠异常凝血酶原的研究

用灵敏的凝血酶原蛇毒激活测定法,观察二乙基亚硝胺诱发大鼠肝癌过程中,血浆异常凝血酶原及肝组织内凝血酶原前体含量的变化。血浆异常凝血酶原从诱癌第4周开始持续上升至第13周;第15周有所下降,第20周又开始回升。而在此过程中,肝组织内凝血酶原前体含量变化不明显,而在诱癌20周的肝癌结节内,凝血酶原前体显著堆积。同时,还研究了肝再生过程中大鼠血桨异常凝血酶原及肝内凝血酶原前体的变化。华法令处理的大鼠作为阳性对照。

Studies on Abnormal Prothrombin in Rats With Hepatocellular Carcinoma

In the course of hepatocarcinogenesis induced by diethylnitrosamine(DEN) administration, the dynamics of plasma abnormal prothrombin showed a saddle-like curve, maintaining a high level from the 4th to the 13th week, then decreasing at the 15th week and rising again at the 20th week.There was no obvious changes of prothrombin precursors in rats liver before the 20th week, but prothrombin precursors were accumulated in cancer nodules of rats in the 20th week. Both the plasma abnormal prothrombin and microsomal precursors were normal during the liver regeneration in rats. Rats treated with warfarin were observed as a positive control