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| 大鼠眶额叶皮质受损破坏新异性探索行为 | |
| 引用本文： | 王秀松,付玉,马漫修,张俊俊,马原野. 大鼠眶额叶皮质受损破坏新异性探索行为[J]. 动物学研究, 2009, 30(5): 527-533. DOI: 10.3724/SP.J.1141.2009.05527 |
| 作者姓名： | 王秀松 付玉 马漫修 张俊俊 马原野 |
| 作者单位： | 1. 中国科学院昆明动物研究所,灵长类认知实验室,云南,昆明,650223;中国科学院研究生院,北京,100049 2. 中国科学院昆明动物研究所,灵长类认知实验室,云南,昆明,650223;云南大学,信息学院电子工程系,云南,昆明,650091 3. 中国科学院生物物理研究所,脑与认知科学国家重点实验室,北京,100101 4. 厦门大学,人工智能研究所,艺术认知与计算机实验室,福建,厦门,361005 5. 中国科学院昆明动物研究所,灵长类认知实验室,云南,昆明,650223 |
| 基金项目： | 国家自然科学基金项目，CASC项目 |
| 摘 要： | 利用旷场测试和Y-迷宫测试两种行为模型检测了双侧眶额叶（orbitofrontal cortex, OFC）电损伤或假损伤雄性SD大鼠的新异性探索行为, 探讨了OFC在大鼠探索新异环境中的作用。旷场测试的结果发现，OFC损伤大鼠的行走距离和直立次数较假损组有明显降低；同时，在Y-迷宫测试中与假损伤组大鼠相比，OFC损伤大鼠在新异臂的访问时间和穿梭次数明显降低。提示眶额叶皮质在大鼠新异性探索行为中起着重要作用。 |
| 关 键 词： | 眶额叶皮质；电损伤；新异性探索；旷场；Y-迷宫；大鼠 |
| 收稿时间： | 2009-02-19 |
Lesions to the Orbitofrontal Cortex Produce the Novelty-Seeking Behavior Deficits in Rats |
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| WANG Xiu-song,FU Yu,MA Man-xiu,ZHANG Jun-jun,MA Yuan-ye,(. Laboratory of Primate Neuroscience Research,Kunming Institute of Zoology,the Chinese Academy of Sciences,Kunming,China,. Graduate University of the Chinese Academy of Sciences,Beijing. Lesions to the Orbitofrontal Cortex Produce the Novelty-Seeking Behavior Deficits in Rats[J]. Zoological Research, 2009, 30(5): 527-533. DOI: 10.3724/SP.J.1141.2009.05527 | |
| Authors: | WANG Xiu-song FU Yu MA Man-xiu ZHANG Jun-jun MA Yuan-ye (. Laboratory of Primate Neuroscience Research Kunming Institute of Zoology the Chinese Academy of Sciences Kunming China . Graduate University of the Chinese Academy of Sciences Beijing |
| Affiliation: | WANG Xiu-song1,2,FU Yu1,3,MA Man-xiu4,ZHANG Jun-jun5,MA Yuan-ye1,(1. Laboratory of Primate Neuroscience Research,Kunming Institute of Zoology,the Chinese Academy of Sciences,Kunming,650223,China,2. Graduate University of the Chinese Academy of Sciences,Beijing,100049,3. Department of Electronic Engineering,Information School,Yunnan University,Kunming 650091,4. State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Beiji... |
| Abstract: | Using the open-field and Y-maze behavioral paradigms to assess the novelty-seeking behavior of the male Sprague-Dawley rats that received bilateral electrolytic lesions of the orbitofrontal cortex (OFC) or sham lesions, we examined the role of the OFC on exploration of the novel environment. In the open-field task, the rats with OFC lesions exhibited the reduced average ambulation distance and average rearing number when compared with the animals with sham lesions. In the meanwhile, the rats with OFC lesions showed the less duration of visits and number of entries in the novel arm in the Y-maze task than the control animals. The current findings suggest that the OFC plays an important role on the novelty-seeking behavior in rats. |
| Keywords: | Orbitofrontal cortex Electrolytic lesions Novelty-seeking Open-field Y-maze Rat |
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