Evidence for the hydrolysis of topical applied liposomal lipids in human stratum corneum |
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Authors: | Zellmer Sebastian |
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Affiliation: | Labsoft Diagnostics AG, Robert-Franz-Ring 21, 06108 Halle, Germany. zellmer@labsoft.de |
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Abstract: | Liposomes were incubated with an extract of human plantar stratum corneum. The liposomal lipids were hydrolysed, if composed of soy-bean phosphatidylcholine or phosphatidylglycerol. Rigid lipids were not degraded. The temperature optimum of the hydrolysis was between 30-35degC. CaCl enhanced, while EDTA reduced the rate of hydrolysis, indicating that the hydrolysis is due to a phospholipase A(2). |
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