Interaction of modified cyclodextrins with cytochrome P-450 |
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Authors: | Ishikawa Minoru Yoshii Hidefumi Furuta Takeshi |
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Institution: | Department of Biotechnology, Faculty of Engineering, Tottori University, Tottori, Japan. |
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Abstract: | The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methyl-beta-CD inhibited CYP1A2 and CYP2D6 at higher concentrations. |
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