Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain |
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Authors: | Rui Zhu Yuan Ji Lianchun Xiao Angabin Matin |
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Institution: | (1) Department of Cancer Genetics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1006, Houston, Texas 77030, USA;(2) Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA;(3) Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA |
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Abstract: | Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge
efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here we
report the identification of candidate disease genes from a CSS by using a combination of genetic and genomic approaches and
by using knowledge about the germ cell tumor disease etiology. We used the CSS 129.MOLF-Chr19 chromosome substitution strain,
in which males develop germ cell tumors of the testes at an extremely high rate. We were able to identify three protein-coding
genes and one microRNA on chromosome 19 that have previously not been implicated to be testicular tumor susceptibility genes.
Our findings suggest that changes in gene expression levels in the gonadal tissues of multiple genes from Chr 19 likely contribute
to the high testicular germ cell tumor (TGCT) incidence of the 129.MOLF-Chr19 strain. Our data advance the use of CSS to identify
disease susceptibility genes and demonstrate that the 129.MOLF-Chr19 strain serves as a useful model to elucidate the genetics
and biology of germ cell transformation and tumor development.
Electronic supplementary material The online version of this article (doi: ) contains supplementary material, which is available to authorized users. |
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