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Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics
Authors:Leif S Ludwig  Caleb A Lareau  Jacob C Ulirsch  Elena Christian  Christoph Muus  Lauren H Li  Karin Pelka  Will Ge  Yaara Oren  Alison Brack  Travis Law  Christopher Rodman  Jonathan H Chen  Genevieve M Boland  Nir Hacohen  Orit Rozenblatt-Rosen  Martin J Aryee  Jason D Buenrostro  Vijay G Sankaran
Institution:1. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;2. Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA;3. Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA;4. Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA;5. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;6. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;7. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;8. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;9. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA;10. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;11. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;12. Society of Fellows, Harvard University, Cambridge, MA 02138, USA;13. Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;14. Harvard Stem Cell Institute, Cambridge, MA 02138, USA
Abstract:
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  • Keywords:lineage tracing  single cell genomics  somatic mutations  mitochondrial DNA  mtDNA  sequencing  hematopoiesis  chronic myeloid leukemia  colon cancer
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