A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10LacZ allele |
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| Authors: | Xiao Dong Xue Wataru Kimura Bo Wang Keisuke Hikosaka Tatsuo Itakura Tadayoshi Uezato Masashi Matsuda Haruhiko Koseki Naoyuki Miura |
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| Affiliation: | 1. Department of Biochemistry, Hamamatsu University School of Medicine, 1‐20‐1 Handa‐yama, Higashi‐ku, Hamamatsu, Shizuoka, Japan;2. Developmental Genetics Group, RIKEN Center for Allergy and Immunology, 1‐7‐22 Suehiro, Tsurumi‐ku, Yokohama, Kanagawa, Japan |
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| Abstract: | To study the expression/function of Tbx10, a T‐box gene, Tbx10LacZ/+ mice were established by replacing the T‐box coding region with a LacZ gene. X‐gal staining showed that LacZ+ cells were localized to two‐cell populations in rhombomere 4 and rhombomere 6. No significant differences in the locations of LacZ+ cells were found between Tbx10LacZ/+ and Tbx10LacZ/LacZ mice, and the Tbx10LacZ/LacZ mice were viable and fertile. We found that the LacZ+ cells are present in both embryonic and adult mice. Histological studies suggest that the rhombomere 4‐derived LacZ+ cells are a subpopulation of the ventral interneurons in the pons. |
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| Keywords: | Tbx10 interneuron rhombomere pons |
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