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Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus
Authors:Jessica Marcandalli  Brooke Fiala  Sebastian Ols  Michela Perotti  Willem de van der Schueren  Joost Snijder  Edgar Hodge  Mark Benhaim  Rashmi Ravichandran  Lauren Carter  Will Sheffler  Livia Brunner  Maria Lawrenz  Patrice Dubois  Antonio Lanzavecchia  Federica Sallusto  Kelly K. Lee  David Veesler  Neil P. King
Affiliation:1. Università della Svizzera italiana, Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland;2. Department of Biochemistry, University of Washington, Seattle, WA, USA;3. Institute for Protein Design, University of Washington, Seattle, WA, USA;4. Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden;5. Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden;6. Institute of Microbiology, ETH Zürich, Switzerland;7. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;8. Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA;9. Vaccine Formulation Laboratory, University of Lausanne, Epalinges, Switzerland;10. Vaccine Formulation Institute, Godalming, UK;11. Biological Physics Structure and Design Program, University of Washington, Seattle, WA, USA;12. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA;13. European Virus Bioinformatics Center, Jena, Germany
Abstract:
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  • Keywords:computational protein design  self-assembly  vaccines  respiratory syncytial virus  nanoparticles  neutralizing antibodies
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