Serological differences in two Blastomyces dermatitidis isolates from different geographical regions of North America |
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Authors: | Axtell R C Scalarone G M |
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Institution: | (1) Department of Biological Sciences, Idaho State University, Pocatello, Idaho, USA |
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Abstract: | Yeast phase lysate antigens were prepared from two isolates (T-58 and ERC-2) from different geographic locations, Tennessee
and Wisconsin. These lysate were evaluated with respect to their ability to detect antibody in dogs infected with blastomycosis
and rabbits immunized with the lysates by an enzyme linked immunosorbent assay (ELISA). Both the dog sera and rabbit sera
assays demonstrated that there were serological differences in these two isolates, which implied that there was antigenic
variance in geographical populations of B. dermatitidis. These results correlated with a previous molecular study that indicated that there are genetic differences in different
geographical populations of the organism.
This revised version was published online in June 2006 with corrections to the Cover Date. |
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Keywords: | Blastomyces dermatitidis blastomycosis ELISA geographical differences lysate antigens serology |
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