Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry |
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| Authors: | Chatterjee, Delphi Khoo, Kay-Hooi McNeil, Michael R. Dell, Anne Morris, Howard R. Brennan, Patrick J. |
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| Affiliation: | 1Department of Microbiology, Colorado State University Fort Collins, CO 80523, USA
2Department of Biochemistry, Imperial College of Science, Technology, and Medicine London SW7 2AZ, UK |
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| Abstract: | The application of extracellular arabinases from aCellulomonassp. and fast atom bombardment-mass spectrometry (FAB-MS) providednew insight into the structure of lipoarabinomannan (LAM) ofMycobacterium tuberculosis, a key molecule in the pathogenesisand physiology of the tubercle bacillus. Previously, the non-reducingarabinan ends of LAM from the virulent (Erdman) strain of M.tuberculosiswere shown to be capped by short (a1 |
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