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Configuration of latent varicella-zoster virus DNA. |
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| Authors: | P Clarke T Beer R Cohrs D H Gilden |
| Abstract: | The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected human ganglia. |
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