Photoreactive threading agent that specifically binds to abasic sites in DNA |
| |
| Authors: | Martelli Alain Jourdan Muriel Constant Jean-François Demeunynck Martine Dumy Pascal |
| |
| Affiliation: | LEDSS UMR 5616 and ICMG-FR2607, Université Joseph Fourier, BP 53, 38041 Grenoble Cédex 9, France. |
| |
| Abstract: | We report the synthesis and study of a photoreactive nitrobenzamide containing acridine that specifically interacts at abasic site in DNA by threading intercalation and introduces under irradiation a lesion on the opposite strand at the unpaired pyrimidine. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
