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Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission |
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| Authors: | Schwarz Alexandra Juarez Jenny Ancca Richards Jean Rath Bruno Machaca Victor Quispe Castro Yagahira E Málaga Edith S Levy Katelyn Gilman Robert H Bern Caryn Verastegui Manuela Levy Michael Z |
| Affiliation: | a Laboratory of Genomics and Proteomics of Disease Vectors, Institute of Parasitology, Biology Centre of the Academy of Sciences of Czech Republic, ?eské Bud?jovice, Czech Republic b Laboratorio de Investigación y Desarrollo, Universidad Peruana Cayetano Heredia, Lima, Peru c Asociación Benéfica Prisma, Lima, Peru d Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, PA, USA e Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA f Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA |
| Abstract: | Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease. |
| Keywords: | Triatoma infestans Impregnated net Sentinel guinea pig Saliva Antibody response |
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