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Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene |
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| Authors: | Cupit Pauline M Steinauer Michelle L Tonnessen Bradley W Eric Agola L Kinuthia Joseph M Mwangi Ibrahim N Mutuku Martin W Mkoji Gerald M Loker Eric S Cunningham Charles |
| Institution: | a Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA b College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA c Centre for Biotechnology Research and Development, Kenya Medical Research Institute, Nairobi, Kenya |
| Abstract: | A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya. |
| Keywords: | Schistosoma Polymorphism Tetraspanin-2 Genotype Kozak sequence Vaccine |
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