HLA antigens in a sample of the Spanish population: Common features among Spaniards,Basques, and Sardinians |
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Authors: | A. Arnaiz-Villena S. Rodriguez de Córdoba F. Vela J. C. Pascual J. Cerveró A. Bootello |
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Affiliation: | (1) Servicio de Immunología, Centro Ramón y Cajal, Cta. Colmenar Km. 9,100, Madrid-34, Spain |
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Abstract: | Summary Frequencies of recently described HLA-A,-B (antigens or splits) and HLA-C and HLA-DR antigens are studied in a 450 normal Spaniards sample. The linkage disequilibria are also calculated. HLA-DR7 is more frequent than in any other population studied. Aw30-B18 and Aw33-B14 associations are common and specific Spanish, Basque, and Sardinian HLA features. A11-B27 association is found in our Spanish sample and also in Basques.HLA-Bw4,-Bw6 antigens are analyzed by family mating and segregation and also using unrelated individuals. It shows a good fit as a genetic system. HLA-B antigens are included either in Bw4 or Bw6 according to expectations from other Caucasoid population results. The possibility of a common and North African origen (Iberians) for Spaniards, Basques, and Sardinians is discussed on the basis of presently available HLA data. |
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