DNA electrochemical sensor based on an adduct of single-walled carbon nanotubes and ferrocene |
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| Authors: | Yang Xiaoying Lu Yanhong Ma Yanfeng Liu Zunfeng Du Feng Chen Yongsheng |
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| Institution: | (1) School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, China;(2) Center for Nanoscale Science and Technology and Key Laboratory for Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University, Tianjin, China |
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| Abstract: | A novel electrochemical sandwich-type gene sensing system was designed by using a DNA probe (DNA-probe1) immobilized on a
gold electrode, the target DNA, and another DNA probe (DNA-probe2) conjugated on a single-walled carbon nanotubes/ferrocene
(Fc–SWNT) adduct. In this sandwich-type gene-sensing electrode, the Fc–SWNT adduct could significantly amplify the electrochemical
response of the reduction of H2O2. The target DNA could be detected selectively and sensitively based on the much enhanced electrochemical catalytic property
of the Fc–SWNT adduct toward H2O2 reduction. |
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| Keywords: | DNA Electrochemistry Immobilization Single-walled carbon nanotubes |
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