Effects of an inhibitor of adenosine deaminase,deoxycoformycin, and of nucleoside transport,propentofylline, on post-ischemic recovery of adenine nucleotides in rat brain |
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Authors: | J W Phillis M H O'Regan |
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Institution: | (1) Department of Physiology, Wayne State University School of Medicine, 540 E. Canfield, 48201 Detroit, MI |
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Abstract: | The effects of an adenosine deaminase inhibitor (deoxycoformycin, 500 μg/kg) and of an inhibitor of nucleoside transport (propentofylline,
10 mg/kg) on adenosine and adenine nucleotide levels in the ischemic rat brain were investigated. The brains of the rats were
microwaved before, at the end of a 20 min period of cerebral ischemia (4 vessel occlusion+hypotension), or after 5, 10, 45,
and 90 min of reperfusion. Deoxycoformycin increased brain adenosine levels during both ischemia and the initial phases of
reperfusion. AMP levels were elevated during ischemia and after 5 min of reperfusion. ATP levels were elevated above those
in the non-treated animals after 10 and 45 min of reperfusion. ADP levels were elevated above the non-drug controls at 90
min. These increases in ATP, ADP and AMP resulted in significant increases in total adenylates during ischemia, and after
10 min and 90 min of reperfusion. Propentofylline administration resulted in enhanced AMP levels during ischemia but did not
alter adenosine or adenine nucleotide levels during reperfusion in comparison with non-treated controls. |
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Keywords: | Deoxycoformycin propentofylline adenine nucleotides adenosine cerebral ischemia |
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