| 神经干细胞/前体细胞分化的功能学鉴定研究进展 |
| |
| 引用本文： | 朱奇,李小永,蒋星红.神经干细胞/前体细胞分化的功能学鉴定研究进展[J].生物化学与生物物理进展,2008,35(8):886-891. |
| |
| 作者姓名： | 朱奇 李小永 蒋星红 |
| |
| 作者单位： | 苏州大学医学部神经生物学教研室,衰老与神经疾病实验室,苏州,215123 |
| |
| 摘 要： | 神经干细胞／前体细胞分化是神经生物学研究的热点．以往对神经干细胞／前体细胞分化水平的鉴定主要依赖于形态学指标，而随着膜片钳技术的应用，神经干细胞／前体细胞分化过程中膜电特性的改变、离子通道活动等功能学指标越来越受到重视．综述了利用膜片钳技术研究神经干细胞／前体细胞功能分化的最新进展，并对存在的问题做出思考和展望．
|
| 关 键 词： | 神经干细胞／前体细胞 细胞分化 膜片钳 电生理 |
| 收稿时间： | 2007/12/21 0:00:00 |
| 修稿时间： | 2008/3/21 0:00:00 |
Progress in The Functional Identification of Neural Stem Cell / Neural Precursor Differentiation |
| |
| ZHU Qi,LI Xiao-Yong and JIANG Xing-Hong.Progress in The Functional Identification of Neural Stem Cell / Neural Precursor Differentiation[J].Progress In Biochemistry and Biophysics,2008,35(8):886-891. |
| |
| Authors: | ZHU Qi LI Xiao-Yong and JIANG Xing-Hong |
| |
| Institution: | Department of Neurobiology, Laboratory of Aging and Nervous Disease, Medical College of Soochow University, Suzhou 215123, China;Department of Neurobiology, Laboratory of Aging and Nervous Disease, Medical College of Soochow University, Suzhou 215123, China;Department of Neurobiology, Laboratory of Aging and Nervous Disease, Medical College of Soochow University, Suzhou 215123, China |
| |
| Abstract: | The differentiation of neural stem cells/neural precursors (NSCs/NPs) is a hot spot in neurobiological research. It used to identify their differentiation degree only by morphologic appearances. The functional characteristics, such as electrical properties of cellular membrane and ion channel activities, are drawing more and more attention with the development of patch clamp technique. It was summarized the recent progress in the study of NSCs/NPs' functional differentiation using patch clamp, some existing problems and research perspectives were suggested. |
| |
| Keywords: | neural stem cells/ neural precursors cellular differentiation patch clamp electrophysiology |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
