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Evidence that presynaptic changes are involved in the expression of LTP and LTD of NMDA receptor-mediated EPSCs in area CA1 of the hippocampus
Authors:K. A. Clark  G. L. Collingridge  
Affiliation:1. Centre for Neuroscience, Crichton St, The University of Edinburgh, Edinburgh, UK;2. Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK;1. School of Materials, University of Manchester, M13 9PL, Manchester, UK;2. Ceramics and Construction Materials Department, College of Materials Engineering University of Babylon, Al Hillah, Iraq;1. Department of Physics, Research Center for Academic Excellence in Applied Physics, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand;2. Department of Physics and General Science, Faculty of Science and Technology, Chiang Mai Rajabhat University, Chiang Mai 50300, Thailand;3. Integrated Nanotechnology Research Center, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand;1. School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, PR China;2. Advanced Ceramics Institute of Zibo New & High-Tech Industrial Development Zone, 255000, PR China;3. School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China;4. Departement of Materials Science and Engineering, North China University of Technology, Beijing 100144, PR China;1. Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan;2. Faculty of Health Science, Osaka Yukioka College of Health Science, 1-1-41 Sojiji, Ibaraki, Osaka 567-0801, Japan;3. Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5, Takayama, Ikoma, Nara 630-0192, Japan;1. Translational Neuropharmacology, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA;2. FORUM Pharmaceuticals Inc, Waltham, MA, USA
Abstract:Plasticity of NMDA receptor-mediated synaptic transmission was studied in the CA1 region of the hippocampus utilising whole cell patch-clamp recording techniques. LTP was associated with a decrease in CV whereas LTD was accompanied by an increase in CV and a decrease in Pr. These data are consistent with LTP and LTD being an opposite expression of the same fundamental process.
Keywords:long-term potentiation   long-term depression   coefficient of variation   probability of transmitter release (Pr)   NMDA receptor
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