GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins |
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| Authors: | Matthias Geyer Alfred Wittinghofer |
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| Affiliation: | aMax-Planck-Institut für medizinische Forschung, Abteilung Biophysik Jahnstraße 29, 69120 Heidelberg, Germany;bMax-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Rheinlanddamm 201, Postfach 10 26 64 44139, Dortmund, Germany |
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| Abstract: | Cell biology depends on the interactions of macromolecules, such as protein—DNA, protein—protein or protein—nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact witht these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated |
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| Keywords: | Abbreviations: Ftase farnesyl transerase GAP GTpase-activating protein GDF GDI dissociation factor GDI GDP-dissociation inhibitor GEF guanine nucleotide exchange factor NTF2 nuclear transport factor 2 PTase prenyl transferase RBD Ras-binding domain rmsd root mean square deviation |
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