Reactive extraction and reextraction of penicillin with different carriers |
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| Institution: | 1. School of Civil Engineering, The University of Queensland, Campus St. Lucia - AEB Ed 49, St Lucia, 4067, QLD, Australia;2. Instituto de Grasa, Spanish National Research Council (CSIC), Ctra. de Utrera, km. 1, Seville, Spain;3. Departamento de Ingeniería Química y Ambiental, Escuela Técnica Superior de Ingeniería, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092, Seville, Spain;1. College of Materials Science and Engineering, Fuzhou University, Fujian Province 350108, China;2. State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;3. Shanghai Key Lab of Chemical Assessment and Sustainability, Shanghai, China;4. Collaborative Innovation Center for Regional Environmental Quality, Beijing, China;5. Key Laboratory of Eco-materials Advanced Technology (Fuzhou University), Fujian Province University, China;1. Department of Clinical Laboratory, Peking University People''s Hospital, Beijing 100044, People''s Republic of China;2. Department of Clinical Laboratory, China Meitan General Hospital, Beijing 100028, People''s Republic of China;3. Laboratory Medicine, Department of Clinical Medicine, Peking University Health Science Center, Beijing 100191, People''s Republic of China;1. College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guian New Area 550025, PR China;2. The Research Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar 161006, PR China |
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| Abstract: | The extraction and reextraction of Penicillin G was investigated with different reactive components. The degrees ER of reextraction and EG extraction + reextraction were evaluated as a function of the pH value, carrier and penicillin concentrations. Besides Amberlite LA-2, nine different reactive components were tested and diisotridecylamine was found to be the most suitable one. The quaternary ammonium salt Adogen 464 is suitable also for the extraction of penicillin. However, the reextraction is incomplete. Therefore, sodium salt of p-toluene sulfonic acid was used as counter-ion, and it was regenerated by NaOH or Cl− anion. The advantages of the use of quaternary ammonium salts are discussed. |
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